Multisystemic Aspects of Neurology and Interdisciplinary Collaboration

It also highlights the bidirectional influence between neurology and non-neurological domains, advocating for collaboration across specialties.

It aims to contextualize how neurological conditions can extend beyond the CNS/PNS and how systemic diseases can present with neurological symptoms.

• Overview and objective:
• The issue introduces a Collection focused on the multisystemic nature of neurological disease, emphasizing that nervous system pathology often intersects with other organ systems.
• Design, scope, and commissioning:
• The Collection comprises specially commissioned material alongside previously published Nature Reviews Neurology content from the prior three years.

It illustrates how dysfunction or injury in one organ can adversely impact the other, using concrete exemplars to illustrate these links.

It explores potential mechanisms behind bladder and sexual dysfunction in these populations and reviews current treatment and management strategies.

• Heart–brain interplay:
• One commissioned Review, led by Matthias Endres and colleagues, analyzes bidirectional interactions between cardiac and cerebral health.
• Urogenital manifestations in CNS disease:
• A second commissioned Review by Ryuji Sakakibara and colleagues surveys urogenital dysfunction across CNS disorders, including Alzheimer disease, Parkinson disease, and spinal cord injury.

Stroke neurologist Luciano Sposato discusses brain–heart interactions and his efforts to advance collaboration between neurology and cardiology.

Uro-neurologist Jalesh Panicker reflects on urinary and sexual dysfunction in neurological disease and his role in shaping guidelines for neurologists.

• Frontline perspectives at the neurology–other disciplines interface:
• The Collection features Q&As with leaders actively bridging neurology with other specialties.

Notably, infectious diseases with neurological impact recur as a theme, including post-COVID autonomic symptoms, cerebral malaria, and HIV-associated cognitive impairment.

Together, these items broaden the contextual landscape for multisystem involvement in neurology.

• Recurring and cross-cutting themes:
• Beyond the two primary reviews, the issue aggregates relevant Nature Reviews Neurology content from the preceding three years that align with multisystemic themes.
• Additional topics:
• Other included topics cover fatigue, neurological complications of cancer therapy, systemic determinants of brain health, and the association between Gaucher disease and Parkinson disease.

This approach underlines a dynamic view of multisystemic neurology rather than a static snapshot.

• Living resource model:
• The Collection is described as a living resource, with plans to update and expand content to better depict barriers to and opportunities for cross-disciplinary collaboration between neurology and other specialties.

It also does not present numerical data, effect sizes, or explicit conclusions from the individual reviews.

Where information is limited or not reported in the source, this is noted here as not disclosed within the summary.

• Reporting boundaries:
• The provided synopsis does not detail specific study methodologies, quantitative outcomes, or the strength of evidence for the cited relationships.

• Contextual value:
• By foregrounding inter-organ interactions and cross-specialty collaboration, the Collection invites clinicians to consider multisystem considerations in neurological assessment and to engage with non-neurology colleagues in care planning and guideline development.
• Open questions: