This PubMed record describes a review article entitled "De‑Escalating and Discontinuing Immunotherapies in Patients With NMOSD and MOGAD." The article appears in Neurology (2026 Sep 22;107[6]:e218482), with electronic publication on 2026 Aug 26. The listed DOI is 10.1212/WNL.0000000000218482. The PubMed identifier is PMID 42647788 and the PubMed Central identifier is PMCID PMC13528907.
The record classifies the manuscript as a Review. PubMed provides links to the journal site and a free full text version on PubMed Central.
The review is authored by Yael Hacohen and a multinational team. Affiliations reported on the PubMed record include academic and clinical centers in the United Kingdom, France, Spain, the Netherlands, the United States, South Korea, Canada, and Germany. Specific institutional listings in the record include Queen Square MS Centre and UCL Queen Square Institute of Neurology (United Kingdom); Great Ormond Street Hospital for Children (United Kingdom); Hôpital Neurologique Pierre Wertheimer (France); Multiple Sclerosis Centre of Catalonia, Vall d'Hebron Barcelona Hospital Campus (Spain); Erasmus Medical Center (the Netherlands); Mayo Clinic (USA); National Cancer Center (South Korea); University of British Columbia (Canada); University Hospital Münster (Germany); and other affiliated centers.
The presence of multiple international centers and neuroimmunology specialty groups indicates a collaborative, multidisciplinary authorship, as presented in the PubMed metadata.
The article title specifies the clinical topic: de‑escalation and discontinuation of immunotherapies for patients with NMOSD (neuromyelitis optica spectrum disorder) and MOGAD (myelin oligodendrocyte glycoprotein antibody‑associated disease). As a review, the manuscript likely addresses considerations around reducing intensity of therapy or stopping immunomodulatory or immunosuppressive treatments in these antibody‑associated demyelinating disorders.
Important clinical keywords reflected in the record include immunotherapies, NMOSD, and MOGAD. The PubMed entry itself, however, does not include the article abstract or the review text in the view provided for this task; therefore, specific clinical content, summaries of evidence, suggested algorithms, or practice recommendations are not available from the supplied source text.
Publication details supplied in the PubMed record:
The PubMed page includes links to full text sources: a journal site link (Atypon) and a direct PubMed Central link for the free full text. Readers seeking the full review should follow those links from the PubMed entry to access the complete article and any supplementary materials.
The PubMed content provided here contains comprehensive bibliographic metadata and author affiliation information but does not include the article abstract or main text in the extract used to create this summary. Because of that, this editorial rewrite does not contain any of the review’s clinical conclusions, evidence syntheses, recommended de‑escalation strategies, patient selection criteria, safety data, relapse rates, monitoring protocols, or other clinical recommendations — none of which were reported in the available source text for this task.
To avoid introducing inaccuracies, no clinical statements, recommendations, or study results have been inferred or invented. Any substantive clinical details must be obtained from the article’s abstract and full text.
The PubMed record provides two direct routes to the complete manuscript:
Recommended next steps for clinicians and researchers: access the PMC full text to review the authors’ evidence synthesis and recommendations regarding de‑escalation and discontinuation of immunotherapies in NMOSD and MOGAD. For citation or detailed methods, consult the article DOI and the PubMed record. If further clarification is needed after reading the review, consider contacting the corresponding author(s) listed in the full text or reviewing cited primary studies within the article.
Note: This rewritten content is limited to the bibliographic and access information present on the PubMed record used as the sole source. The original PubMed extract supplied for this task did not include the article abstract or body; therefore, clinical details from the review are not summarized here because they were not reported in the available source text.