The PubMed entry reports an article titled "Site-Specific Apo AI Glycation Impairs HDL Function and Promotes Atherosclerosis in Diabetes" published in Circulation (doi: 10.1161/CIRCULATIONAHA.125.078171). The citation on the PubMed page lists the journal issue and pages as 2026 Sep 22;154(12):1088–1108, with electronic publication noted as Epub 2026 Aug 25.
The article lists a multi-institutional author group. Several authors are identified as contributing equally. Affiliated institutions named on the PubMed record include the Department of Cardiovascular Medicine and Institute of Translational Medicine at Shanghai Jiao Tong University, Rui Jin Hospital, the National Facility for Protein Science Shanghai, the Shanghai Advanced Research Institute (Chinese Academy of Sciences), the Shanghai Institute of Biochemistry and Cell Biology, and other collaborating departments and centers within Shanghai Jiao Tong University and associated research institutes.
From the title alone, the work addresses the biochemical modification of apolipoprotein A‑I (ApoA‑I) by glycation at site-specific residues, the downstream effect on HDL function, and a proposed mechanistic contribution to atherosclerosis in the setting of diabetes. The title indicates a direct linkage among three concepts: ApoA‑I glycation, impaired HDL functionality, and promotion of atherosclerotic disease in diabetic conditions.
The PubMed entry highlights these primary keywords through the title; however, the entry does not include the article abstract or full study text in the provided excerpt. Consequently, details such as which ApoA‑I residues were glycated, the biochemical assays used to assess HDL function, models used to evaluate atherosclerosis, or clinical versus preclinical scope are not available from the excerpt.
The public-facing PubMed record included with this task provides bibliographic content and navigation features common to NCBI entries: title, authors, affiliations, date, volume and pagination, DOI, and links to full-text sources (publisher/Atypon). It also contains account navigation, links to related resources, and entry management options (save, email, collections). The PubMed page references a full-text link hosted by the publisher where the complete article and supporting information are presumably available.
The excerpt supplied here does not contain the article abstract or any of the following: objectives, experimental design, methods, datasets, key findings, numeric results, statistical analyses, interpretations, limitations, or author conclusions. Because those items are not present in the source text provided, no specific experimental results, effect sizes, or evidence-based conclusions can be stated or paraphrased.
For clarity and to avoid inference beyond the source text: the title implies a mechanistic association but does not substitute for reported data. The exact nature and strength of the associations, whether findings derive from in vitro biochemical assays, animal models, human clinical samples, or a combination, and any recommendations or clinical implications are not reported in the PubMed excerpt available here.
The PubMed entry includes a full-text link (publisher/Atypon). To review experimental methods, data, figures, statistical analyses, and the authors’ discussion and conclusions, readers should consult the publisher’s full-text version via the provided DOI link or the journal’s website. For researchers or clinicians seeking to apply insights from this work, obtaining and critically appraising the full article is required to assess study design, translational relevance, and validity of the reported associations between ApoA‑I glycation, HDL dysfunction, and atherosclerosis in diabetes.
This PubMed record documents a peer-reviewed article that focuses on site-specific glycation of ApoA‑I and its putative impact on HDL function and atherosclerosis in diabetes, published in Circulation with full bibliographic citation and author affiliations. The bibliographic entry alone does not provide the study’s methods, results, or conclusions. Those details must be obtained from the publisher-hosted full text to evaluate the evidence and implications for research or clinical practice.