This record summarizes the bibliographic metadata for a 2026 Molecular Cancer Therapeutics article titled “TNIK Overexpression Is Sufficient for Chemoradiation Resistance in Limited-Stage Small Cell Lung Cancer.” The publication is indexed at PubMed (PMID 41838988) and is available as a free full text via PubMed Central (PMCID PMC13339944). The DOI is 10.1158/1535-7163.MCT-25-0529.
The listed authors include Dipanwita Dutta Chowdhury, Eddie L Imada, Nick Connis, Jinhee Chang, Aaron Chan, and numerous collaborators. Several authors are noted to have contributed equally to the work. Affiliations span multiple academic centers and disciplines, including the Division of Translational Radiation Sciences, Department of Radiation Oncology at the University of Maryland Baltimore School of Medicine; Departments of Pathology and Laboratory Medicine at Weill Cornell Medicine; Departments of Oncology and Radiation Oncology at Johns Hopkins University School of Medicine; and the Institute for Genome Sciences at the University of Maryland School of Medicine. The multi-institutional author list indicates a collaborative effort involving radiation oncology, pathology, molecular radiation sciences, biochemistry, and genome sciences.
The article’s title asserts that overexpression of TNIK is sufficient to produce chemoradiation resistance in limited-stage small cell lung cancer (SCLC). This phrase represents the principal claim as presented in the bibliographic record and serves as the central finding reported by the authors in the published article.
The article is accessible through the journal’s platform and via the free PMC full-text link included in the PubMed record.
The content provided here is limited to the PubMed record and front-matter metadata (title, authors, affiliations, indexing information). The supplied excerpt does not contain the article abstract, figures, methods, results, statistical analyses, or discussion text. Consequently, specific information about experimental design (for example, whether the study used in vitro cell lines, in vivo models, patient tumor specimens, or clinical cohorts), the magnitude of effect of TNIK overexpression, mechanistic pathways implicated, validation cohorts, or any therapeutic interventions tested is not available from this excerpt.
Where the PubMed record or title states a finding, that assertion reflects what the authors reported; however, the supporting data and methodological details required to evaluate the claim are not included in the supplied text.
If the authors’ claim that TNIK overexpression is sufficient to cause chemoradiation resistance in limited-stage SCLC is supported by robust experimental and/or clinical evidence in the full article, the finding could have several implications:
Biomarker development: TNIK expression could be examined as a predictive biomarker of response to standard chemoradiation in limited-stage SCLC.
Mechanistic insight: Identifying pathways by which TNIK contributes to resistance could reveal targets for combination strategies to overcome treatment failure.
Therapeutic targeting: If inhibitors or modulators of TNIK exist or can be developed, they may warrant preclinical and clinical evaluation in SCLC to restore sensitivity to chemoradiation.
These implications are general and inferential; the PubMed excerpt does not provide evidence, validation results, or a discussion of therapeutic approaches. Readers should consult the full article for the authors’ presented data and interpretations.
The PubMed entry links to the full text at PubMed Central (PMCID PMC13339944) and to the journal site via DOI. For complete information on study design, models or cohorts used, experimental methods, quantitative results, statistical methods, figures, and the authors’ discussion and conclusions, consult the full-text article. The PubMed record also lists author affiliations and contribution notes for context.
Note: This summary is based solely on the bibliographic and header information present in the supplied PubMed record. Specific experimental details, numerical results, and internal conclusions from the article’s abstract, results, and discussion were not included in the provided source text and therefore are not reported here.